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You may not be a good fit for GLP-1 drugs if you: Have a history of pancreatitis Live with severe gastrointestinal disorders Have a personal or family history of medullary thyroid cancer or MEN 2 Are pregnant or breastfeeding Mild side effects such as nausea, digestive discomfort, or fatigue are common, especially when starting treatment

Experimentally, one-month regimen of exenatide in rats increased the length and weight of the small intestine by 9% and 31%, respectively 6 , consistent with our own observations that the rats had an average increase of 43% in the small intestine length after 3-month treatment of polyethylene glycol (PEG)-exenatide (data not shown)

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However, the early onset of reduced craving suggests at least some direct central nervous system effects