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Diabetes therapy : research, treatment and education of diabetes and related disorders

However, these tolerability issues ultimately impeded its regulatory and clinical progression

Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists: A State-of-the-Art Narrative Review

We selected appropriate confounders, such as index year, sex, age, diabetes duration, health screening variables, comorbidities, and antidiabetic drugs, for PS matching to minimize the influence of factors other than GLP-1 RA exposure

When the effort required by rodents to obtain palatable food was assessed, exendin-4 was found to decrease operant responding on both fixed and progressive ratio schedules, further supporting a reduction in the motivational drive for palatable foods ( However, it is worth noting that most preclinical studies do not incorporate a dose titration phase, a gradual increase to the therapeutic maintenance dose, which is standard in clinical settings