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One 2024 study at the Smell and Taste Center at the University of Pennsylvania (source) found evidence of GLP1 agonists significantly depressing the perception of all five basic taste qualities. Interestingly, while all participants in the study experienced a slight decline in their sense of smell, it was not considered statistically significant suggesting that olfactory changes may be more individualised, or more complex to detect in standardised tests

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Gray SM, et al

By using a GLP-1 medication by itself , patients ended up with lower bone density after 1 year of treatment
Supplementary material The Supplementary Material for this article can be found online at: References 1 BohonowychJMillerJMcCandlessSEStrongTV
13,45 In STEP HFpEF, semaglutide improved in KCCQ clinical summary scores (CSS), one of the studys primary endpoints, by 7.8 points compared with placebo