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In male and female OAB patients receiving darifenacin (532 with 1315 without concomitant diabetes), the presence of diabetes was associated with smaller improvements of urgency, incontinence, frequency, and nocturia in a multivariate analysis adjusting for gender, age, and baseline symptoms, but the impact of diabetes was small relative to the overall symptom improvement by darifenacin (Schneider et al

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But retatrutide adds a direct hepatic mechanism on top of those indirect benefits

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