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In a mouse model of Huntingtons disease, an inherited neurodegenerative disorder, Ashwagandha extract improved motor performance, reduced the size of toxic protein aggregates (striatal inclusion bodies), and extended survival (Mohd Sairazi and Sirajudeen 2020)

Why Blood Sugar May Not Be Very High In classic DKA: Insulin deficiency severe hyperglycemia In euglycemic DKA: Some insulin is still being administered Blood glucose may appear only mildly elevated But insulin is insufficient to prevent ketogenesis This can delay recognition because: Patients and clinicians may not suspect DKA with glucose under 250 mg/dL Symptoms may initially resemble dehydration or GI illness Additional Contributing Factors GLP-1 use in Type 1 diabetes may also increase DKA risk due to: Vomiting dehydration stress hormones ketone rise Intentional insulin reduction due to fear of hypoglycemia Reduced basal insulin during weight loss Increased glycemic variability from delayed gastric emptying Hypoglycemia and the Insulin Reduction Trap Another issue is the cycle that can develop: Appetite decreases Insulin dose is reduced Hypoglycemia occurs intermittently Insulin is reduced further Ketone production increases Over time, this can push the patient into metabolic instability

Starting doses range from 150mg to 200mg weekly for men, split into two injections to maintain stable blood levels

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Dysfunction in GLP-1R signaling has been implicated in multiple pathologies, including type 2 diabetes mellitus (T2DM), obesity, atherosclerosis, Parkinsons disease (PD), Alzheimers disease (AD), non-alcoholic steatohepatitis (NASH), and several cancers