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For appetite and craving changes, the 60 to 90 day window is more realistic

Zepbound should be considered a complementary therapy , especially valuable for those who are: At The Respire Institute, were committed to staying on the forefront of sleep medicine combining new research with evidence-based practice to give our patients every advantage in their care

Using medication beyond this window increases contamination risk and may reduce treatment effectiveness

Aranha MM, Cortez-Pinto H, Costa A, da Silva IB, Camilo ME, de Moura MC, et al

The trial's primary insulin-sensitivity endpoint was null across the whole group, with benefits appearing in subgroups such as people with low baseline Akkermansia and those with prediabetes ( Suenaert et al., 2026 )