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Competing interests: All authors have completed the ICMJE uniform disclosure form at and declare: support from Swedish Cancer Society, Swedish Research Council, Karolinska Institutet, Novo Nordisk Foundation, Lundbeck Foundation, Independent Research Foundation Denmark, Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, and Danish Cancer Society for the submitted work

Binding mechanisms: DPP-4 inhibitors' binding modes can be grouped into three main classes that interact in different manners with specific sites on the DPP-4 enzyme: Class 1: Saxagliptin and vildagliptin bind to specific sites on the DPP-4 molecule, saxagliptin/S1 and saxagliptin/S2, and form a bond with Ser630

Through drug price negotiations, governments and pharmaceutical companies can work together to determine equitable pricing structures that facilitate patient access to treatments without imposing excessive financial strain on the healthcare system

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Semaglutide is the first drug to be approved for cardiovascular risk reduction in this population.