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Esophageal varices, which are abnormally dilated vessels within the esophagus, are typically seen in patients with portal hypertension and chronic liver disease and these patients are at an increased risk for hemorrhage

Similarly, STZ-induced alpha-cell GLP-1 production partially protected rat islets from further beta-cell loss (95)

While SELECT demonstrated compelling outcomes, stakeholders will likely look for further evidence to substantiate the benefits of weight management with Wegovy outside the controlled setting of a clinical trial, e.g., in real world studies to confirm effectiveness and safety in routine medical practice when treating large numbers of patients of greater diversity, or via the SELECT-LIFE extension study, which invites SELECT patients to participate in a 10-year observational follow-up to evaluate long-term benefits