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Obesity and type 2 diabetes remain critical global health challenges, with rising prevalence demanding innovative treatment approaches

Exposures Two cohorts were assembled, with the first composed of patients who started and continued on GLP-1 receptor agonists or DPP-4 inhibitors between 1 January 2007 and 31 December 2020 and the second composed of patients who started and continued on GLP-1 receptor agonists or SGLT-2 inhibitors between 1 January 1 2013 and 31 December 2020

This advanced formula features targeted probiotic strains including Akkermansia muciniphila and Clostridium butyricum, organisms associated with gut barrier integrity, short-chain fatty acid production, and healthy microbiome diversity

Until recently, therapeutic strategies remained limited to lifestyle interventions, with few pharmacological options demonstrating meaningful clinical benefit