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As of 2026, retatrutide has not received marketing authorisation from the MHRA or EMA and is only accessible within authorised clinical trials

GLP-1 RAs improve CV outcomes, as well as secondary outcomes such as progression of renal disease, in patients with established CV disease or chronic kidney disease (CKD)

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Additionally, Wegovy is approved for children aged 12 and older whose BMI falls at or above the 95th percentile for their age and sex

As these drugs entered wider clinical use, it became clear that their impact extended well beyond blood sugar controlraising early questions for actuaries about how the therapies might affect long-term health risk and insurance costs