tirzepatide hair loss studies and Loss: Causes, Clinical Evidence and What Really Helps with Mounjaro and Zepbound Why does hair fall out
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Preserve lean mass with resistance training and protein, keep intake under a modest deficit when safe, and increase daily monitoring of appetite and weight so small trends can be corrected early
schedule light-to-moderate activity (resistance + walking/NEAT)
The best medication is the one you can tolerate and continue long term

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

Lonardo A, Nascimbeni F, Ballestri S, et al
