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Description
Dedicated mechanistic studies, such as the REMODEL and SMART studies, are required to confirm if the observed initial reduction in eGFR with semaglutide reflects a salutary hemodynamic effect or can be explained by other factors

doi: 10.1016/0026-0495(87)90153-3 58 NauckMAHeimesaatMMOrskovCHolstJJEbertRCreutzfeldtW

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Leptin Receptor Mutations Leptin receptor mutations can also occur in the LEPR gene
There is already meaningful interest in oral GLP-1 treatment before these medications have fully launched in the UK