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Key Safety Considerations: The FDA mandates a boxed warning regarding thyroid C-cell tumors

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Slow dose escalation mitigates these effects substantially, and discontinuation due to gastrointestinal intolerance ranges from 3% to 16% across agents, being highest for GLP-1/glucagon dual agonists (e.g., survodutide)

Schmidt was diagnosed with a traumatic brain injury and severe postconcussion syndrome with no cure

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