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The 2022 Consensus Report by the American Diabetes Association and the European Association for the Study of Diabetes called for more clinical evidence on the kidney-protective effects of SGLT2 inhibitors and GLP-1 receptor agonists in low-risk populations, Jensen and colleagues wrote

Compounded formulations undergo rigorous quality testing and must comply with USP standards, ensuring potency and sterility equivalent to branded alternatives

So for the moment, retatrutide is the exciting newcomer on the horizon, while semaglutide and tirzepatide are the current champions in practice

It's by no means a guarantee that a lower dose translates to lower side effects, he says