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Though GLP-1 RAs are not first-line therapies, this class of medications is suggested for adult type 2 diabetics with cardiovascular risks, is preferred to insulin when possible, and is recommended in combination therapy with insulin if insulin must be used [6]

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There is also evidence that activation of thermogenesis has other positive impacts on metabolic functions, such as insulin resistance, hyperglycemia, and elevated blood lipids, which may provide other benefits to those on GLP-1RA [80]