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Surampudi adds that while we dont know of any direct interaction between alcohol and semaglutide that makes the drug less effective, drinking too much alcohol in general can slow weight loss efforts. Since alcohol can lower inhibitions and lead to overeating, it may make it harder for some people to achieve their weight loss goals, especially at higher levels of consumption

[DOI] [PubMed] [Google Scholar] 62.Alvarez E, Roncero I, Chowen JA, Thorens B, Blazquez E

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A mouse model study showed that GLP-1 can decrease macrophage activity in adipose tissue-the expression and production of IL-6, TNF-, MCP-1, and NF-B together with JNK activation [101]

If the drug is so effective at stimulating weight loss, then shouldnt everyone that is obese or struggling with weight control use it