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The final approved dosing regimen may differ from what was used in trials
For type 2 diabetes, NICE guidance (NG28) recommends GLP-1 receptor agonists in specific circumstances, including when triple therapy with metformin and two other oral drugs is not effective, not tolerated or contraindicated
[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Zhang L., Li C., Zhang Z., Zhang Z., Jin Q.Q., Li L., Hlscher C
Notably, the only property all these poly-ligands share is that they all activate the GLP-1R, albeit with varying potencies (Figure 3)
PMID: 37296162
