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In rodents, GLP-1 has been shown to increase the biosynthesis of glucose transporter 2 (GLUT-2) and glucokinase [29]

However, it is unclear which of these, the size increase or HSA binding, are more pharmacologically relevant and account for the observed extension of the half-life

Cardiovascular risk reduction with liraglutide: an exploratory mediation analysis of the LEADER Trial

The half-life of oral semaglutide is approximately 1 week, aligning with subcutaneously administered form (102)

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