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Patients who could benefit the most from these drugs may not be able to afford them [184], [193]

[DOI] [PubMed] [Google Scholar] 761.Moreno C., Mistry M., Roman R.J

Currently, there is no direct evidence that GLP-1RA use contributes to progression of pancreatic cysts to PDAC, but this remains an important knowledge gap for future investigations considering the high prevalence of pancreatic cysts in the general population (~ 10% by age 50 and ~25% by age 70) 56

It is noteworthy that although GLP-1 and insulin combination therapy may provide convenience in practice, combination therapy comes at the cost of diminished dosing flexibility of both drugs, raising concerns about whether the specific combination therapy actually achieves better therapeutic efficacy than two drugs that are titrated separately