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Supplementary Materials The following supporting information can be downloaded at Author Contributions Conceptualization, R.O.T

If an unacceptable increase in cardiovascular risk was not discharged at the interim analysis, the SURPASS-4 trial was to continue until accrual of 133 participants with MACE-4 occurred

A note confirming review of the Certificate of Analysis (COA) for the semaglutide base API

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