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While this is a single case and cannot determine class effects, it is a data point worth noting

For instance, in STZ-diabetic mice the GIPR agonist, (D-Ala 2 )GIP, improved bone quality and halted matrix degradation, ultimately enhancing fracture resistance

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Studies of the structure of class C G-protein coupled receptors (GPCRs) have provided insight on the specific interactions between peptides and receptors (3840), and the findings from such studies are aligned with the results from the original Ala scan