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Nonspecific binding was determined in the presence of excess (15 M) unlabelled ghrelin or GLP-1

Practical Application Polyphenol-rich foods: Pomegranates, cranberries, blueberries, green tea Prebiotic fibers: Garlic, onions, leeks, asparagus Omega-3 sources: Fatty fish, walnuts, flaxseeds, chia seeds Fermented foods: Yogurt, kefir, sauerkraut, kimchi Avoid excessive antibiotics: When possible, preserve gut bacteria diversity Limit artificial sweeteners: May negatively impact beneficial bacteria Regular exercise: Supports beneficial bacterial populations Adequate sleep: 7-9 hours supports microbiome balance Strategy 4: Fatty Acid Signaling for L-Cell Activation The Science: L-cells express receptors that detect specific fatty acids in the intestinal lumen

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