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We may speculate that a larger reduction of plasma aldosterone in the patients with advanced CKD seen in our study could be caused by a higher local activity of RAAS due to kidney dysfunction

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In a study comparing the effects of semaglutide and tirzepatide for weight loss, those receiving tirzepatide were more likely to achieve 5% or greater, 10% or greater, and 15% or greater weight loss and experienced larger reductions in body weight at 3, 6, and 12 months