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Morphological studies demonstrated a particularly high density of GLP-1R expression in the PVN of mice (Cork et al., 2015), rats (Merchenthaler et al., 1999

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At present, it would be prudent to consider an HbA1c target of 58 mmol/mol for most patients with type 2 diabetes and DN-CKD if they are on an insulin-dominant regime, and a target of up to 68 mmol/mol in older patients with more advanced CKD, especially where they have renal anaemia

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These results should be interpreted with a qualified healthcare provider and do not predict exact medication responserather, they offer context for individual metabolic phenotypes and may support more informed treatment planning

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