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glp-1 receptor agonist and dpp-4 inhibitor combination contraindicated DPP4 Inhibitors vs Agonists | June 2021 | Clinical Corner Mechanism of action for GIP,
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In fact, they may be better suited to complement your GLP-1 journey, instead of replacing it

Diabetes Med (2000) 17(1):339

Nat Rev Nephrol 13 , 605628 (2017)

These medicines are generally well tolerated, although gastrointestinal side effects are common during treatment initiation or dose escalation
A recent 2025 study showed that participants who consumed 1 gram of berberine daily for 6 months had no meaningful change in adiposity (AKA the accumulation of body fat) 19
