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However, those protections dissipated once tirzepatide was removed from the shortage list, so compounding pharmacies and outsourcing facilities can be held in violation of the law to the extent they still compound copies

It is not typically recommended for anyone younger, and eligibility is determined by a healthcare professional after reviewing medical history and health risks

In one study, patients who took tirzepatide saw an average reduction in their HbA1c levels (a measure of blood sugar control) of 2.4%, compared to 1.7% for patients who took insulin

During the shortage, clinicians are also required to: Only prescribe GLP-1 RAs for their licensed indication Review the need for prescribing a GLP-1 RA agent and stop treatment if no longer required due to not achieving desired clinical effect as per NICE CG28 Avoid switching between brands of GLP-1 RAs, including between injectable and oral forms Where a higher dose preparation of GLP-1 RA is not available, do not substitute by doubling up a lower dose preparation Where GLP-1 RA therapy is not available, proactively identify patients established on the affected preparation and consider prioritising for review based on the criteria below