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This is why they were originally designed as a way to manage diabetes

Dopamine agonists (FDA-approved pramipexole, ropinirole, or rotigotine) are effective but carry risks of augmentation (paradoxical worsening of symptoms) and impulse control disorders with long-term use

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What wasnt initially realized is that GLP-1 receptors are also found in brain regions governing motivation and reward, including the nucleus accumbens, the ventral tegmental area, the amygdala, the hippocampus, and other areas

Several FDA-approval drugs will be discussed, including liraglutide, semaglutide, tirzepatide, orlistat, and combinations like phentermine/topiramate and bupropion/naltrexone, noting their effectiveness in obesity management [34, 35] (Table 1)