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The Three Receptors: What Each One Does Retatrutide's three target receptors each contribute a distinct metabolic function: GLP-1R reduces appetite and slows gastric emptying, GIPR enhances insulin secretion and glucose handling, and GCGR increases hepatic energy mobilisation and fatty acid oxidation

These drugs mimic the hormone glucagon-like peptide-1, which boosts insulin production, slows digestion and regulates appetite, helping to lower blood sugar and support weight management

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In light of this evidence, these therapies have opened a new paradigm not only for the management of altered glucose metabolism in T2D but also in consideration of their pleiotropic effects (1, 20)

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