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Most gastrointestinal side effects such as nausea and early satiety peak during the dose-escalation phase and substantially improve within 48 weeks as the body adapts to the medication

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Metformin uses improved liver ultrasound imaging and the levels of aminotransferases, particularly ALT, according to a meta-analysis of 13 prospective trials, but it did not significantly enhance all patients histologic findings

HbA1c is your 3-month average blood sugar, so a reduction confirms a real metabolic win