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They're all injectable GLP-1 medications, they all work on appetite and metabolism, and they're all backed by clinical trial data

After 2 or more missed weeks, the GI adaptation partially reverses, which means restarting at a full dose may cause nausea that you had previously overcome
Insulin resistance alters nutrient partitioning, potentially directing fewer resources toward muscle preservation

Further studies in DR models have elucidated additional protective pathways