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Common side effects include nausea, upset stomach, diarrhea, or tiredness, especially when you first start taking it
Although a low number of psychiatric adverse events were reported in this study, 20 patients had a fatal or life-threatening outcome among the severe clinical outcomes associated with the three drugs
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Expert opinion on drug metabolism & toxicology, 17(9), 11391148 7

The pathological cascade of brain insulin resistance lies in the fact that this resistance increases A plaque deposition and tau protein hyperphosphorylation in the interior of the affected AD brain areas