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In cancer, IL-6 can either be pro- or anti-inflammatory depending on the context and can thus demonstrate pro- or anti-tumor effects 44

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Lack of Directionality in Staging Current staging systems do not indicate whether fibrosis is progressing or regressing within a stage, which makes it difficult to assess the true impact of treatment on disease progression4

or symptoms of significant dehydration such as dizziness, reduced urination, or inability to keep fluids down
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