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Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

Pericyte-specific Kir6.1 knockout mice were generated by crossing tamoxifen-inducible NG2-Cre ERT2 knock-in mice 68 (kindly donated by Frank Kirchhoff, University of Saarland) and floxed (flx) Kir6.1 mice (kindly donated by Andrew Tinker, QMUL) to allow deletion of Kir6.1 in NG2-expressing pericytes after oral gavage of tamoxifen

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The second is tirzepatide: Mounjaro is approved for diabetes and Zepbound for weight management again, same molecule, two names

For renal impairment, although most GLP-1 agents have minimal renal clearance, impaired kidney function increases the risk of adverse events such as dehydration from vomiting or decreased drug clearance in polypharmacy