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-cell senescence has been reported to be induced by chronological aging 12 and by systemic treatment with the insulin-receptor antagonist, S961, which acutely induces of -cell-specific senescence and hyperglycemia in mice 1,12

1,29 If ketoacidosis persists despite administration of D5W, dextrose 10% may be used

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Maarbjerg SJ, Borregaard J, Breitschaft A, Donsmark M, Sndergaard F