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Interpreting this evidence for real-world application requires careful consideration of the trial conditions

As per FDA approval in 2021, it's indicated for chronic weight management in adults with obesity or overweight with at least one weight-related condition such as high blood pressure, type 2 diabetes mellitus or high cholesterol (hyperlipidemia)

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Significant and clinically meaningful dose-dependent HbA1c reductions were specifically observed in patients taking 4mg-12mg of Retatrutide, and the same held true for weight loss

Therefore, suppressing PFKFB3-driven excessive glycolysis could be a promising therapeutic strategy for pulmonary fibrosis