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A small number of specialized weight loss practices have reported exploring this pairing in carefully selected patients, but no large-scale efficacy or safety data exists in peer-reviewed journals

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Sanyal et al.: Phase 3 Trial of Semaglutide in Metabolic DysfunctionAssociated Steatohepatitis (ESSENCE) nej.md/3EVFAFM

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Type 1C3 aldosterone reductase (AKR1C3) is the only enzyme expressed in adipose tissue that can convert androstenedione into testosterone, which is widely expressed in the adipose tissue of patients with PCOS [63]

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However, currently, no trial has directly examined the effects of this combination therapy

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