maintaining weight loss after glp-1 maintenance discontinuing : r/Zepbound How to Maintain Weight Loss

Flux through the glycolytic pathway is tightly controlled through regulation of glycolytic enzyme activity by allosteric modulation, post-translational modifications as well as transcriptional control

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This accomplishes two things: it reduces GI side effects that can be harder to tolerate when youre already managing disease-related fatigue and symptoms, and it gives you and your care team time to watch for any changes in disease activity

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In these cases, alternative formulations such as injectables or non-oral routes may be preferable