do not combine dpp-4 inhibitors with glp-1 receptor agonists recommendation DPP4 Inhibitor Mechanism of Action – My Endo Consult DPP-4 inhibitors and GLP-1RAs: cardiovascular
Description
Arillotta D, Floresta G, Papanti Pelletier GD, Guirguis A, Corkery JM, Martinotti G, Schifano F

"Tirzepatide is an Imbalanced and Biased Dual GIP and GLP-1 Receptor Agonist." JCI Insight, 2020, 5(17), e140532

Given emerging evidence of both metabolic and direct cardiovascular actions, a comprehensive synthesis of cardiovascular outcome trial data is required to clarify the efficacy and safety of this drug class

Multiple studies have found many adults with CKD or at risk for CKD do not have urinary albumin-to-creatine ratio (UACR), a key biomarker for CKD, measured on an annual basis
A licensed provider in your state then reviews the information and recommends a course of action
