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It is an additional higher-dose option for patients who may need further weight reduction

Circulating ghrelin levels are elevated during energy restriction and in anticipation of eating [2] and are decreased following a meal [3]

Both tirzepatide and semaglutide have long half-lives and stay in the body for several days to weeks

Zepbound led to 6.5% more weight loss than Wegovy in a head-to-head clinical trial

Currently, there is insufficient evidence to support the use of GLP-1 in treating binge eating disorder, but some studies suggest it may be helpful.18 Ongoing assessment and open discussions about the risks are recommended for this population.19 Clinical Efficacy: Weight Management, Type 2 Diabetes, and Cardiovascular Protection Weight Management Weight loss remains a primary reason individuals begin GLP-1 medications, and the STEP clinical trial program has been instrumental in evaluating the efficacy of semaglutide 2.4 mg for chronic weight management across diverse populations, with study participants recruited from a wide range of countries