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[129] The pens possibly contained insulin, and led to several people being hospitalised with hypoglycemia and seizures

When GIP and glucagon receptor activation are added, appetite regulation may become broader and more durable, although the relative contribution of each receptor remains incompletely defined

By combining the two drugs, researchers were hoping to preserve muscle mass during weight loss

However, in a co-agonist molecule, glucagon receptor activation occurs alongside GLP-1 and, in the case of retatrutide, GIP receptor activation

Dosing is adjusted progressively rather than maximized immediately, which reduces the likelihood of adverse reactions