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The 12mg group showed the most pronounced effects across all measured endpoints, but the 8mg group demonstrated a favorable balance between efficacy and tolerability

Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism

Therefore, many modifications have been made to GLP-1 to increase its biological half-life and consequently its efficacy in vivo
Miholic J, Orskov C, Holst JJ, Kotzerke J, Meyer HJ
