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Description
Significant weight loss typically occurs over several months, depending on adherence to the treatment plan

[It creates] an unhealthy feedback loop: The thing they need to do to help control their pain is too painful for them to do. The Benefits of GLP-1 Drugs By helping patients lose weight, GLP-1s may enable them to have a surgery that could restore their movement and reduce their pain enough to be able to resume exercise

The most clinically relevant interaction is with oral medications that require consistent absorption timing, since semaglutide slows gastric emptying and can alter how quickly other drugs reach the bloodstream

The carbohydrate target is under 20 to 50 grams of net carbohydrates per day depending on individual metabolic flexibility

Progressive proximal muscle weakness (affecting shoulders and hips more than hands and feet) may indicate an inflammatory myopathy or other serious neuromuscular condition that requires investigation beyond simply attributing symptoms to GLP-1 therapy
