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Compare this to the indefinite treatment paradigm of pharmaceutical GLP-1 medications, where the expectation is continuous use and discontinuation typically leads to rebound

Other medications, like acid-reducing drugs, may increase the risk

The study made headlines at the 2026 American Society of Clinical Oncology (ASCO) annual meeting in June

Between 2021 and 2024, global sales of Ozempic surged from US$5.3bn to US$18.9bn, while Wegovy amassed global sales of US$9.2bn

To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs