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see also review by Brierley & de Lartigue, 2021), or even elsewhere close to the circulation, which in turn release glutamate and peptide cotransmitters within the lower brainstem to convey postprandial satiation signals to the CNS (Figure 1)

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2003;285:R470478

Mol Med Rep (2016) 14(4):36628.10.3892/mmr.2016.5729 50 CrespelADe BoisvilliersFGrosLKervranA

Overweight individuals with T2DM should reduce energy intake while maintaining a balanced diet rich in nutrient-dense foods like fruits, vegetables, whole grains, lean proteins, and healthy fats, limiting added sugars, sodium, and saturated fats [148]