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Once injectable semaglutide (Ozempic) goes off-patent in 2032, there is a substantial likelihood of market erosion for Rybelsus

Semaglutide, a relatively new medication used for treating type 2 diabetes and obesity, is one such drug that requires specific knowledge and skills to inject correctly

Among these, sodium-glucose co-transporter 2 inhibitors (SGLT2-Is) and GLP-1RAs proved to have several vascular actions going beyond simple antihyperglycemic effects

In germ-free mice without gut microbiota, there was no circadian rhythm of insulin secretion

Stopping the drugs without a clear medical reason could work against those benefits, the authors noted