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Obesity affects more than 40% of U.S

Beyond improving the metabolic profile, GLP-1 RAs have been shown to significantly reduce serum levels of CRP In summary GLP-1 receptor agonists have been shown to be effective in reducing body weight, measurements of liver injury, and liver fat content

Thyroid function tests (TSH, free T4) should be checked at baseline, 6-8 weeks after achieving maintenance dose of the weight loss medication, and every 3-6 months during active weight loss to ensure appropriate thyroid hormone replacement

Another study demonstrated a remarkable 42% reduction in glucose area under the curve and a 40% reduction in insulin area under the curve compared to placebo

The 56-week trial involved patients without type 2 diabetes and a BMI of at least 30 (or a BMI of at least 27 if they had treated or untreated dyslipidemia or hypertension)