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The amount of water affects not only dosing math but also stability, injection comfort, and shelf life

However, these findings do not translate to humans

104 The most common side effect for both GLP-1RAs and metformin is moderate gastrointestinal discomfort, which can be soothed by gradual dose titration, eating small portions meals but with a higher frequency, and avoiding some compounds, including stimulant or secretory substances (caffeinated beverages, spices) and those known to cause relaxation of lower esophageal sphincter (fatty, fried or processed foods, chocolate, tomato, mint)

Weight loss continues at a steady but slightly decelerating pace

The American Diabetes Associations Standards of Medical Care in Diabetes2020 recommend that use of SGLT2s and GLP-1s be considered in patients with or at high risk for cardiovascular disease, kidney disease, or heart failure regardless of patients current A1c or A1c target