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Genetic variants in GLP1R, GIPR, FTO, and MC4R genes reflect how your body may respond to GLP-1 agonists and diet interventions

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The in vivo effects of AT-7687 were evaluated in obese cynomolgus monkeys, and when combined with the GLP-1 analogue liraglutide, AT-7687 enhances weight reduction induced by liraglutide and improves glycemic control and lipid metabolism (51)

Given that GIP has vasodilatory properties, we postulate that this peptide may contribute to the pathophysiology of the post-prandial worsening of POTSs symptoms, which needs to be tested in future studies

This finding holds particular importance given no medications currently target both alcohol reduction and smoking cessation simultaneously