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LIMITATIONS OF CURRENT EVIDENCE AND GAPS IN KNOWLEDGE Despite the increasing information on gut microbiota as a modulator of antidiabetic drug effects, there are still systematic and conceptual gaps in the data available

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Are there side effects with oral GLP-1 therapy
A comprehensive analysis of 43,365 individuals from two US healthcare databases indicated that GLP-1 RAs do not elevate the risk of pulmonary aspiration during upper gastrointestinal endoscopy in patients with T2DM when compared to SGLT-2 inhibitors, yielding a pooled risk ratio of 0.98 (95% CI, 0.73 to 1.31) among GLP-1 RA users
