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Abbreviations AICAR: Aminoimidazole carboxamide ribonucleotide AMPK: AMP-activated protein kinase DPP-4: Dipeptidyl peptidase-4 GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide 1 GLP1R: GLP-1 receptor HBSS: Hanks balanced salt solution LKB1: Liver kinase B1 PPAR: Peroxisome proliferator-activated receptor References Nathan DM, Buse JB, Davidson MB et al (2009) Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy

This geographic concentration also heightens vulnerability to regional political instability, labor disputes, and natural disasters, as few alternative growing regions can quickly compensate for local disruptions

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